Lisa R. Young, MD, is Chief of the Division of Pulmonary and Sleep Medicine at Children’s Hospital of Philadelphia (CHOP) and Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania (Penn). She holds the John M. Keating Endowed Chair, Presidential Scholar at CHOP and is Associate Director of the Penn-CHOP Lung Biology Institute.
She was an undergraduate at the University of Virginia where she was a Jefferson Scholar and then earned her MD and completed residency training in Pediatrics and Internal Medicine at Duke University. She completed fellowship training in Pediatric Pulmonology and Adult Pulmonary/Critical Care Medicine at Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, and then joined the faculty at Cincinnati Children’s. In 2011, she relocated to Vanderbilt University, where she was an Associate Professor of Pediatrics, Medicine, and Cell & Developmental Biology, Director of the Center for Childhood Lung Research and the Pediatric Rare Lung Diseases Clinical Program, and the Janie Robinson and John Moore Lee Endowed Chairholder in the Department of Pediatrics.
Dr. Young provides clinical care and leads research focused to individuals with interstitial and other rare lung diseases. One area of focus in her laboratory has been on the roles of type II alveolar epithelial cells in the regulation of pulmonary fibrosis and other genetic causes of lung disease. Utilizing mouse models of Hermansky-Pudlak Syndrome (HPS), her work has provided key evidence that the lung epithelium plays a defining and initiating role in the pathogenesis of pulmonary fibrosis, while also deciphering mechanisms by which signals from the epithelium are transduced by macrophages and fibroblasts. She has also led a clinical study on HPS pulmonary fibrosis through The Rare Lung Diseases Consortium of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Disease Research (ORDR), NCATS and NHLBI that is developing the infrastructure to translate discoveries in the laboratory to patients. In addition, Dr. Young has made significant contributions in Tuberous Sclerosis Complex and Lymphangioleiomyomatosis (LAM) through studies on serum VEGF-D as a biomarker and as a co-investigator in clinical trials that led to the first FDA-approved therapy for this disease.
Dr. Young has led foundational efforts in the field of Childhood Interstitial Lung Diseases (ILD). She is the PI of the 20-center U.S. National Registry and observational study in childhood ILD which provides a platform for a spectrum of clinical and translational research. With collaborators, her work has defined the clinical, radiologic, and histologic features of Neuroendocrine cell Hyperplasia of Infancy (NEHI, a form of childhood ILD), and provided new insights into natural history including persistence of disease manifestations in adults. Studies that identified the first genetic contribution to NEHI have elucidated pathogenesis and created opportunities for further mechanistic investigation.
Dr. Young has a long-standing commitment to education and advocacy for patients and families with rare diseases, and she has organized numerous patient education conferences and provided service through advisory boards for several patient advocacy groups. Her service to the academic community has included NIH grant review, participation on NIH and workshop and other clinical guideline committees, and scientific conference leadership, including FASEB, NIH R13-funded conferences, and as Program Committee Chair for Respiratory Cell and Molecular Biology Assembly of the American Thoracic Society.
She has received multiple awards for her research and advocacy, with examples including the American Thoracic Society Robert B. Mellins Outstanding Achievement Award, the American Thoracic Society Public Advisory Roundtable Excellence Award, and the LAM Foundation Scientific Advancement Award, and the Scientific Advancement award from the Hermansky-Pudlak Syndrome Network. Dr. Young has been awarded a K24 grant for mentoring in Patient-Oriented Research in Pediatric Rare Lung Diseases has mentored fellows in pediatric pulmonary and other training programs, as well as a number of students, residents, and junior faculty.